In this study, we test the effects of genistein treatment on limb bone and growth plate cartilage histomorphometry in obese, hyperglycemic ob/ob mice. Genistein, a phytoestrogen, has been shown by several studies to demonstrate bone-protective properties and may improve bone health in obese type 2 diabetics. Incidences of these conditions are on the rise worldwide. Obesity and type 2 diabetes mellitus are associated with elevated risk of limb bone fracture. Genistein treatment increases bone mass in obese, hyperglycemic mice. Conclusion Our results indicate that genistein treatment affects bone of the tibial midshaft in the ob/ob mouse, independent of improvements in the hyperglycemic state and body weight. Genistein-treated mice also exhibit decreased growth plate thickness of the proximal tibia. However, histomorphometric comparisons show that genistein-treated mice have greater tibial midshaft diameters and ratios of cortical bone to total tissue area than the controls. Results Genistein-treated mice remained obese and hyperglycemic. Cross-sectional geometric and histomorphometric analyses were conducted on tibias. Genistein-treated mice were fed a diet containing 600 mg genistein/kg for a period of 4 weeks. Six-week-old ob/ob mice were divided into control and genistein-treated groups. Methods In this study, we test the effects of genistein treatment on limb bone and growth plate cartilage histomorphometry in obese, hyperglycemic ob/ob mice. Michelin, Richard M Al-Nakkash, Layla Broderick, Tom L Plochocki, Jeffrey HÄ«ackground Obesity and type 2 diabetes mellitus are associated with elevated risk of limb bone fracture. Genistein treatment increases bone mass in obese, hyperglycemic mice The genistein group had significantly lower hepatic lipid peroxidation and higher SOD, CAT, and GPx activities than the control group. Highlights: expression during the early stage of wound healing. Park, Eunkyo Lee, Seung Min Jung, In-Kyung Effects of genistein on early-stage cutaneous wound healingÄOE Office of Scientific and Technical Information (OSTI.GOV)
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